New preprint on the evolution of young TSSs
We have just uploaded our latest manuscript to bioRxiv. This is a paper by Cai Li, a postdoc in our London lab, exploring the birth and rapid initial evolution of transcription start sites in the human genome. The paper describe how repeat sequences, in the right genomic contexts, are an important source of TSSs; how they evolve rapidly in the early stages of formation, driven by mutagenic processes that target repeats; and how they finally settle into being bone fide TSSs in the genome. This is also our first collaborative paper with Boris Lenhard!
Since the beginning of the year, we have also submitted all our papers to bioRxiv as a way to disseminate our research rapidly.