We are a computational biology laboratory with a particular interest in the genome-scale analysis of transcriptional regulation and evolution.
Our goal is to use genomic data to understand:
- How is gene expression regulated?
- How do these mechanisms control interesting biological behaviours?
- How does gene regulation affect evolution?
We use a genomic approach as it allows us to identify common principles that apply to most biological systems. Unique or unusual cases - which always occur in biology - could then be understood within this broader context.
Most of our work depends on publicly available data, but we also collaborate closely with a few experimental laboratories.
Where are we?
Our main laboratory is located at the Lincoln's Inn Field Site of the Francis Crick Institute. We will move to the new Crick building in 2016. We also have a smaller laboratory at the Okinawa Institute of Science & Technology in Japan.